The environmental fate of substances like plant protection products, chemicals and biocides is a vital part of every environmental assessment. Evaluating the degradation of substances is a prerequisite for a variety of further studies and ratings.
Noack Lab is confident to develop and conduct the best possible GLP degradation study design for your specific requirements.
…in the required tier level
Depending on the substance specifics, a broad range of complexity of studies is requested. Our portfolio addresses all tier levels from biodegradation screening studies to higher tier simulation tests.
Screening for ready biodegradability is performed as CO2 Evolution Test/Modified Sturm Test (acc. to OECD 301B), Modified MITI Test (I) (acc. to OECD301C), Closed Bottle Test (acc. to OECD301D), Manometric Respiratory Test (acc. to OECD301F) and CO2 in Sealed Vessels (Headspace Test) (acc. to OECD310). Enhanced tests are possible for every test design
Inherent biodegradation can be tested in the test design of Zahn-Wellens Test / EMPA Test (acc. to OECD 302B) and Modified MITI Test (II) (acc. to OECD 302C).
Finally, we complete the coverage of all common compartments with the biodegradation test in seawater (acc. to OECD306) and the anaerobic biodegradability test (acc. to OECD 311).
At Noack, we perform the following transformation and simulation studies: Aerobic sewage treatment (acc. to OECD 303A) in activated sludge units or porous pots, Aerobic and anaerobic transformation in soil (acc. to OECD 307), aerobic and anaerobic transformation in aquatic sediment (acc. to OECD 308), aerobic mineralization tests in surface water (acc. to OECD 309, incl. specific analysis if required), simulation tests for chemicals discharged to wastewater (acc. to OECD 314) and anaerobic degradation tests in manure. All studies can be performed with 14C-labelled substances.
The degradation of plastics and polymers can be assessed in studies acc. to ISO 14851, 14852, 17556, 19679, and 18830.
Modification of any test design is possible to meet your special needs or requests from authorities. Please don’t hesitate to ask us for your tailor-made test design!
…under appropriate conditions
For a proper simulation of degradation, the actual environmental conditions are of major importance. At Noack Lab, degradation studies can be conducted under aerobic or anaerobic conditions and at different temperatures.
…in different environmental compartments
Degradation and metabolization can vary immensely in different compartments. To assess the different rates and conditions of degradation, studies can be conducted in a variety of compartments, such as activated sludge, sewage treatment plants, surface waters, sediments, compost, soil and sea water.
…including analytical monitoring.
Analytical monitoring can be performed in all relevant matrices such as water, soil, sediment, pore water and organisms. We offer in-house state-of-the-art highly sensitive accompanying chemical analytics using LC-MS/MS or LC-QTOF.
Additionally, analysis of 14C-labelled substances by LSC or LC-FSA is available for simulation studies and, when needed, for OECD 301B.
With more than 30 years of experience, we can analyze a wide range of compound classes as well as their degradation products. All chemical methods are fully validated following the most recent guidelines and specifications of regulatory authorities (SANCO/3029/99 rev. 4, SANCO/3030/99 rev. 4).
All our studies are conducted under GLP and supported by a broad range of experience in scientific work on biodegradation topics. Participation in ring-tests, scientific conferences and workshops allows us to stay up-to-date in current discussions and bringing in our experiences.
We strive for complete transparency and a close communication during the course of your studies. Monthly status updates, guaranteed testing slots and real-time updates are only some examples of our customer service.